Not recommended. The Substance starts with a good premise, develops nicely, but ends in the most revolting 20 minutes since the bathtub scene in Saltburn. Who knows why the Cannes jury awarded the Best Screenplay trophy to this unfunny disappointment? The movie threatens Gran Guignol with an early-on close-up of TV exec Dennis Quaid (Great Balls Of Fire) slobbering down shrimp while horrified actress Elizabeth Sparkle (Demi Moore, Ghost) looks on. It’s Sparkle’s 50th birthday, and she’s too old to keep her job. She turns to a shadowy wonder drug, The Substance, to create a new “her.” A younger girl emerges . . . literally (Margaret Qualley, Poor Things). At this point, an intelligent take on youth and drugs - - read Ozempic - - seems possible; Moore’s poignant enactment of a woman endlessly reconceiving her make-up for a date is promising. But soon after, special effects took the wheel, and the movie degenerated into stupidity.